10.1371/journal.pone.0128707.g002
Tassiane Assíria Fontes Martins
Tassiane
Assíria Fontes Martins
Lívia de Figueiredo Diniz
Lívia
de Figueiredo Diniz
Ana Lia Mazzeti
Ana
Lia Mazzeti
Álvaro Fernando da Silva do Nascimento
Álvaro
Fernando da Silva do Nascimento
Sérgio Caldas
Sérgio
Caldas
Ivo Santana Caldas
Ivo
Santana Caldas
Isabel Mayer de Andrade
Isabel
Mayer de Andrade
Isabela Ribeiro
Isabela
Ribeiro
Maria Terezinha Bahia
Maria
Terezinha Bahia
Anti-<i>Trypanosoma cruzi</i> activity of benznidazole/itraconazole combination therapy.
Public Library of Science
2015
cruzi Y strain
Experimental Chagas Disease
combination therapy
benznidazole
nitroheterocyclic drugs nifurtimox
Chagas disease
2015-06-15 02:54:23
Figure
https://plos.figshare.com/articles/figure/_Anti_Trypanosoma_cruzi_activity_of_benznidazole_itraconazole_combination_therapy_/1449493
<p>Mice were inoculated with 5,000 <i>T</i>. <i>cruzi</i> Y strain trypomastigotes by the intraperitoneal route and treated with daily doses 50, 75 and 100 mg/kg of bodyweight (mg/kg) of benznidazole (Bz) or itraconazole (Itz) alone or in combination for 20 consecutive days. (a) Maximum number of trypomastigotes detected in the peripheral blood of treated mice up to 30 days post-treatment. (b) IgG antibodies in treated mice by ELISA up to 30 days post-treatment. The results are shown as the reactivity index value, which was obtained by dividing the absorption value (O.D. value) of each serum sample by the mean value of the differential control uninfected sample. (-) negative results in fresh blood examination and PCR assay, (+) positive results in fresh blood examination and/or PCR assay, and <b>&</b> significant difference relative to benznidazole treatment administered alone at the same dose; ★ significant relative to itraconazole treatment administered alone at the same dose.</p>