Kumar Putcha, Balananda-Dhurjati Jia, Xu Rao Katkoori, Venkat Salih, Chura Shanmugam, Chandrakumar Jadhav, Trafina C. Bovell, Liselle P. Behring, Michael Callens, Tom Messiaen, Ludwine Bae, Sejong Grizzle, William E. P. Singh, Karan Manne, Upender Down-regulation of <i>RPH3AL</i> mRNA and protein in breast cancers. <p>Analyses of mRNA and protein expression of <i>RPH3AL</i><b>(A)</b> mRNA levels of <i>RPH3AL</i> down-regulated in breast cancers relative to their matching normal tissues. <b>(B)</b> Immunohistochemical staining of RPH3AL in breast cancer tissues. RPH3AL expression was seen predominantly in the cytoplasm of <b>(i)</b> lobular intraepithelial neoplasia (LIN, orange arrow) and adjacent normal cells (green arrow) (X100) <b>(ii)</b> ductal carcinoma in situ (DCIS, red arrow) and adjacent normal cells (green arrow) (X100) <b>(iii)</b> DCIS (red arrow) and invasive carcinoma (dark red) (X200). LIN and DCIS exhibit lower expression of RPH3AL relative to adjacent normal cells. Mild nuclear staining was also seen in a few cells of normal, LIN, DCIS, and invasive carcinoma.</p> ffpe;breast cancers;survival;missense point mutations;TP 53. RPH 3AL;snp;rhp;RPH 3AL;tumor suppressor;rna;dna;17 p 13.1 locus;loh;TP 53 loci;RPH 3AL locus;utr;17 p 13.3 locus;TP 53 locus;RPH 3AL gene 2015-06-12
    https://plos.figshare.com/articles/figure/_Down_regulation_of_RPH3AL_mRNA_and_protein_in_breast_cancers_/1448170
10.1371/journal.pone.0129216.g001