TY - DATA T1 - Platelet PI3Kγ contributes to activated platelets induced intima-media thickening after partial ligation. PY - 2015/06/08 AU - Cuiping Wang AU - Rong Jin AU - Anil Nanda AU - Jinchuan Yan AU - Guohong Li UR - https://plos.figshare.com/articles/figure/_Platelet_PI3K_947_contributes_to_activated_platelets_induced_intima_media_thickening_after_partial_ligation_/1439847 DO - 10.1371/journal.pone.0129265.g001 L4 - https://ndownloader.figshare.com/files/2099580 KW - Platelet activation KW - PI 3K mice KW - platelet PI 3K deficiency KW - ec KW - platelet PI 3K KW - Platelet PI 3K Contributes KW - proinflammatory mediator expression KW - carotid artery ligation KW - PI 3K platelets KW - PI 3K KW - p 38 MAP Kinase KW - Severely Reduced Flow Conditions Studies N2 - (A) Representative Verhoeff’s elastic stained cross sections (level 3) of left common carotid arteries from WT mice treated with PBS (Vehicle), WT platelets (WT plts), or PI3Kγ-/- platelets (PI3Kγ-/- plts) (n = 5 per group) at 21 d after partial ligation. (B) Schematic diagram of partial ligation and tissue microtomy. Intima+ media areas (C) were measured at seven section levels (200μm intervals), and their mean values were determined. Data are expressed as mean ± SEM. * P<0.05 versus vehicle, # P<0.05 versus WT platelet-infused mouse. Light microscope magnification is 10×. ER -