TY - DATA T1 - CD45+ cells, including T cells, infiltrate skeletal muscle after CTX injury. PY - 2015/06/03 AU - Alessandra Castiglioni AU - Gianfranca Corna AU - Elena Rigamonti AU - Veronica Basso AU - Michela Vezzoli AU - Antonella Monno AU - Albert E. Almada AU - Anna Mondino AU - Amy J. Wagers AU - Angelo A. Manfredi AU - Patrizia Rovere-Querini UR - https://plos.figshare.com/articles/dataset/_CD45_cells_including_T_cells_infiltrate_skeletal_muscle_after_CTX_injury_/1435012 DO - 10.1371/journal.pone.0128094.g001 L4 - https://ndownloader.figshare.com/files/4437928 KW - WT KW - Muscle Injury Regulate KW - Tissue Regeneration Muscle injury KW - FOXP KW - T cell recruitment KW - muscle satellite cells KW - muscle precursor cells KW - muscle regeneration KW - T lymphocytes KW - satellite cell differentiation N2 - (A) Percentages of CD45+ cells in skeletal muscle at different time points after CTX injury (n ≥ 3 mice analyzed per time point, mean ± SEM). (B) The number of CD45+ cells in skeletal muscle peaks at day 3 and rapidly decreases thereafter (n ≥ 3 mice per time point, mean ± SEM). (C) The percentage of T cells (red) among muscle-infiltrating CD45+ cells increase with time, passing from a few cells present at day 1 (12 ± 3%, mean ± SD) to 25 ± 7% (mean ± SD) at day 3, and 37 ± 7% and 34 ± 7% (mean ± SD) at day 5 and 7 respectively (n ≥ 4 mice analyzed per time point). (D) The number of CD45+ and CD3+ cells present in muscle at different time points after injury. CD3+ cells increase in number after day 3, remain constant until day 5, and decline by day 7 (n ≥ 3 mice per time point, mean ± SEM). ER -