10.1371/journal.pone.0128313.t001
Ronald W. Irwin
Ronald
W. Irwin
Christine M. Solinsky
Christine
M. Solinsky
Carlos M. Loya
Carlos M.
Loya
Francesco G. Salituro
Francesco G.
Salituro
Kathleen E. Rodgers
Kathleen
E. Rodgers
Gerhard Bauer
Gerhard
Bauer
Michael A. Rogawski
Michael
A. Rogawski
Roberta Diaz Brinton
Roberta
Diaz Brinton
Pharmacokinetic parameters for allopregnanolone in both rabbit and mouse.
Public Library of Science
2015
dose
sedation behavior time course
regenerative treatment regimen
optimized complexation ratio
allopregnanolone mouse plasma levels
differentiation transcription factor NeuroD
pk
creb
allopregnanolone brain exposure
Allopregnanolone Preclinical Acute Pharmacokinetic
5 min
Intravenous allopregnanolone transiently
NOAEL
30 min
pcna
mtd
2015-06-03 03:12:43
Dataset
https://plos.figshare.com/articles/dataset/_Pharmacokinetic_parameters_for_allopregnanolone_in_both_rabbit_and_mouse_/1435011
<p>LC-MS/MS measurements of allopregnanolone in plasma (top panel) or brain (bottom panel) after a single bolus dose (mg/kg body weight) by intravenous (IV), subcutaneous (SC), or transdermal (TD) administration.</p><p>Pharmacokinetic parameters for allopregnanolone in both rabbit and mouse.</p>