TY - DATA T1 - Taiwanin A incorporated polyurethane fiber sheets for prevention of postoperative cancer recurrence PY - 2015/06/09 AU - Onon Batnyam AU - Hideyuki Uematsu AU - Chih-Wei Chou AU - Shin-ichiro Suye AU - Satoshi Fujita UR - https://tandf.figshare.com/articles/dataset/Taiwanin_A_incorporated_polyurethane_fiber_sheets_for_prevention_of_postoperative_cancer_recurrence/1433799 DO - 10.6084/m9.figshare.1433799.v2 L4 - https://ndownloader.figshare.com/files/2092043 L4 - https://ndownloader.figshare.com/files/2092044 L4 - https://ndownloader.figshare.com/files/2092045 KW - cancer cells KW - healing process KW - staple line KW - drug release KW - postoperative complications KW - tract cancers KW - Slight burst release KW - polyurethane fiber sheets KW - mpa KW - drug concentration KW - postoperative cancer recurrence KW - High elasticity KW - taiwanin KW - peristalsis movement KW - prevention N2 - In this study, we propose a single solution for prevention of postoperative complications and recurrence of highly metastatic gastrointestinal tract cancers. Here, we demonstrate preparation and characterization of Taiwanin A incorporated polyurethane fiber sheets with excellent mechanical properties and sustained drug release. Sheets with elastic modulus of 8 MPa and ultimate tensile strength of 30 MPa will provide support on surgical staple line preventing leakage at anastomosis. Slight burst release of the drug within 7 days (15%) and further sustained release will inhibit proliferation and migration of remaining cancer cells and maintain locoregional high drug concentration to prevent recurrence of the disease. High elasticity of the material will promote healing process without impeding natural peristalsis movement of gastrointestinal organs. ER -