10.6084/m9.figshare.1427404.v2
Milan Subedi
Milan
Subedi
Jianbo Chen
Jianbo
Chen
Eunsol Kang
Eunsol
Kang
Kyung Im Kim
Kyung Im
Kim
Youngjoo Byun
Youngjoo
Byun
Facile Synthesis of 2-(4-Hydroxybiphenyl-3-yl)-1<i>H</i>-indoles from Anilines and 5′-Bromo-2′-hydroxyacetophenone
Taylor & Francis Group
2015
pharmacologically
arylboronic acids
hydroxyphenyl
scaffold
hydroxybiphenyl
bromo
synthesis
Arylindole
Facile Synthesis
molecule
aniline
substituent properties
indole cyclization
2015-06-10 18:42:56
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Facile_Synthesis_of_2_4_Hydroxybiphenyl_3_yl_1_i_H_i_indoles_from_Anilines_and_5_Bromo_2_hydroxyacetophenone/1427404
<div><p></p><p>2-Arylindoles are attractive scaffolds because they are found in many pharmacologically active molecules. In this study, we describe the facile synthesis of diverse 2-(2-hydroxyphenyl)-1<i>H</i>-indoles from anilines and 5′-bromo-2′-hydroxyacetophenone in two steps using palladium-catalyzed indole cyclization as a key reaction. The indole cyclization was primarily controlled by the substituent properties of anilines. Suzuki-coupling reactions of 2-(5′-bromo-2′-hydroxyphenyl)-1<i>H</i>-indoles with arylboronic acids provided the corresponding 2-(4-hydroxybiphenyl-3-yl)-1<i>H</i>-indoles in moderate yield.</p></div>