10.6084/m9.figshare.1427404.v2 Milan Subedi Milan Subedi Jianbo Chen Jianbo Chen Eunsol Kang Eunsol Kang Kyung Im Kim Kyung Im Kim Youngjoo Byun Youngjoo Byun Facile Synthesis of 2-(4-Hydroxybiphenyl-3-yl)-1<i>H</i>-indoles from Anilines and 5′-Bromo-2′-hydroxyacetophenone Taylor & Francis Group 2015 pharmacologically arylboronic acids hydroxyphenyl scaffold hydroxybiphenyl bromo synthesis Arylindole Facile Synthesis molecule aniline substituent properties indole cyclization 2015-06-10 18:42:56 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Facile_Synthesis_of_2_4_Hydroxybiphenyl_3_yl_1_i_H_i_indoles_from_Anilines_and_5_Bromo_2_hydroxyacetophenone/1427404 <div><p></p><p>2-Arylindoles are attractive scaffolds because they are found in many pharmacologically active molecules. In this study, we describe the facile synthesis of diverse 2-(2-hydroxyphenyl)-1<i>H</i>-indoles from anilines and 5′-bromo-2′-hydroxyacetophenone in two steps using palladium-catalyzed indole cyclization as a key reaction. The indole cyclization was primarily controlled by the substituent properties of anilines. Suzuki-coupling reactions of 2-(5′-bromo-2′-hydroxyphenyl)-1<i>H</i>-indoles with arylboronic acids provided the corresponding 2-(4-hydroxybiphenyl-3-yl)-1<i>H</i>-indoles in moderate yield.</p></div>