Anatabine reduces the amount of phosphorylated STAT3 immunopositive cells in the hippocampus and cortex of Tg PS1/APPswe mice. Megha Verma David Beaulieu-Abdelahad Ghania Ait-Ghezala Rena Li Fiona Crawford Michael Mullan Daniel Paris 10.1371/journal.pone.0128224.g006 https://plos.figshare.com/articles/figure/_Anatabine_reduces_the_amount_of_phosphorylated_STAT3_immunopositive_cells_in_the_hippocampus_and_cortex_of_Tg_PS1_APPswe_mice_/1425752 <p>A) Representative 40X microscopic fields revealing the presence of phospho-STAT3 immunopositive cells around Congo red stained β-amyloid deposits in the hippocampus and cortex of wild-type mice and Tg PS1/APPswe receiving regular drinking water (placebo), and Tg PS1/APPswe mice receiving anatabine at a dosage of 10 and 20 mg/Kg/Day in their drinking water are shown. Data is presented as mean±SEM. B) The histogram represents the average amount of phospho-STAT3 burden (expressed as a percentage of the brain area examined) quantified in the hippocampus and the cortex of Tg PS1/APPswe mice receiving the regular drinking water (placebo) or anatabine at a dosage of 10 and 20 mg/Kg/Day. ANOVA shows a statistically significant main effect of the anatabine treatment on phospho-STAT3 burden associated with Aβ deposits (P<0.001). Post-hoc analyses reveal statistically significant differences in phospho-STAT3 burden in the hippocampus associated with β-amyloid burden (P<0.045 and P<0.017) and cortex (P<0.001 and P<0.001) between Tg PS1/APPswe placebo and anatabine treated 10 and 20 mg/Kg/Day Tg PS1/APPswe mice. (No immunoreactivity for phospho-STAT3 was observed in the hippocampus and the cortex of wild-type mice).</p> 2015-05-26 15:04:00 anatabine treatment stat ad ps nf Chronic Anatabine Treatment chemical structure similarity Mouse Model β deposits tg Transgenic Mouse Model