TY - DATA T1 - C-index for prediction of accelerated renal function decline (eGFR decline <-3 or >-3 mL/min/1.73m2/year) for a) established risk markers (reference model: baseline UACR, current vs. never smoker, sex, systolic and diastolic blood pressure, use of oral diabetic medication, and baseline eGFR) (C-index = 0.835), b) 3-biomarker model (MMP7, TEK, and TNFR1 on top of reference model) (C-index = 0.835; p = 0.262 compared to reference model), and c) Optimal model (baseline UACR, MMP7, current vs. never smoker, sex, TEK, MMP2, systolic blood pressure, baseline eGFR, TNFR1, NPHS2, CTGF, use of oral diabetic medication, YKL-40, MMP1, MMP13, MMP8, SOST, CCL2, and NT-proCNP) (C-index = 0.896; p = 0.008 compared to reference model). PY - 2015/05/14 AU - Michelle J. Pena AU - Andreas Heinzel AU - Georg Heinze AU - Alaa Alkhalaf AU - Stephan J. L. Bakker AU - Tri Q. Nguyen AU - Roel Goldschmeding AU - Henk J. G. Bilo AU - Paul Perco AU - Bernd Mayer AU - Dick de Zeeuw AU - Hiddo J. Lambers Heerspink UR - https://plos.figshare.com/articles/figure/_C_index_for_prediction_of_accelerated_renal_function_decline_eGFR_decline_3_mL_min_1_73m_2_year_for_a_established_risk_markers_reference_model_baseline_UACR_current_vs_never_smoker_sex_systolic_and_diastolic_blood_pressure_use_of_oral_diabetic_medication/1415618 DO - 10.1371/journal.pone.0120995.g003 L4 - https://ndownloader.figshare.com/files/2068812 KW - ccl KW - Renal Function Decline KW - eGFR decline KW - novel panel KW - lasso KW - prediction KW - outpatient diabetes center KW - data integration approach KW - YKL KW - type 2 diabetes KW - disease pathways KW - Type 2 Diabetes ObjectiveWe KW - ml KW - biomarker KW - ctgf KW - R 2 increase KW - Different Disease Pathways KW - risk markers N2 - C-index for prediction of accelerated renal function decline (eGFR decline <-3 or >-3 mL/min/1.73m2/year) for a) established risk markers (reference model: baseline UACR, current vs. never smoker, sex, systolic and diastolic blood pressure, use of oral diabetic medication, and baseline eGFR) (C-index = 0.835), b) 3-biomarker model (MMP7, TEK, and TNFR1 on top of reference model) (C-index = 0.835; p = 0.262 compared to reference model), and c) Optimal model (baseline UACR, MMP7, current vs. never smoker, sex, TEK, MMP2, systolic blood pressure, baseline eGFR, TNFR1, NPHS2, CTGF, use of oral diabetic medication, YKL-40, MMP1, MMP13, MMP8, SOST, CCL2, and NT-proCNP) (C-index = 0.896; p = 0.008 compared to reference model). ER -