%0 Figure %A Velmurugan, Punitha %A Rao Jonnalagadda, Raghava %A Nair, Balachandran Unni %D 2015 %T Engineering D-Amino Acid Containing Collagen Like Peptide at the Cleavage Site of Clostridium histolyticum - Fig 5 Collagenase for Its Inhibition %U https://plos.figshare.com/articles/figure/_Engineering_D_Amino_Acid_Containing_Collagen_Like_Peptide_at_the_Cleavage_Site_of_Clostridium_histolyticum_Fig_5_Collagenase_for_Its_Inhibition_/1414882 %R 10.1371/journal.pone.0124398.g005 %2 https://ndownloader.figshare.com/files/2067860 %K DAla substitution %K enzyme hydrolysis %K wound healing %K cancer metastasis %K cleavage site %K Protein engineering %K peptide %K Containing Collagen %K matrix proteins %K Clostridium histolyticum Collagenase %K collagenolytic activity %K Inhibition Collagenase %K polyproline II conformation %K dichroic spectroscopy %K region %X

(a) Change of CD spectral signature of DAla substituted peptide with increase in time from 0 to 120 min at 37°C in 2D-view; (b) Change of CD spectral signature of DAla substituted peptide upon interaction with bacterial collagenase with increase in time from 0 to 120 min at 37°C in 2D-view (c) Relative amount of different structural elements in DAla substituted collagen like peptide with increase in time from 0 to 120 min at 37°C using CD data by CONTIN software package; (f) Relative amount of different structural elements in DAla substituted collagen like peptide upon interaction with bacterial collagenase with increase in time from 0 to 120 min at 37°C using CD data by CONTIN software package.

%I PLOS ONE