Kwon, Sugyeong Han, Young Taek Jung, Jong-Wha Studies on the Synthesis of Indothiazinone and Its Derivatives via Direct 3-Acylation of Indole <div><p></p><p>Indothiazinone is a natural 3-acylindole alkaloid, isolated from a culture of myxobacterial strain. It was found to possess antibacterial activity against yeast and filamentous fungi. Indothiazinone is also structurally related with a mammalian endogenous aryl hydrocarbon receptor ligand, (2-(1′<i>H</i>-indole-3′-carbonyl)thiazol-4-carboxylic acid methyl ester (ITE). In this article, the synthesis of indothiazinone has been disclosed for the first time. Key feature includes direct and selective 3-acylation of indole in the presence of Lewis acid. In addition, an efficient preparation of <i>N</i>-substituted indothiazinone derivatives has been demonstrated.</p></div> aryl hydrocarbon receptor ligand;indothiazinone;Lewis acid;myxobacterial strain;Key feature;filamentous fungi;Indole Indothiazinone;ite 2015-06-10
    https://tandf.figshare.com/articles/journal_contribution/Studies_on_the_Synthesis_of_Indothiazinone_and_Its_Derivatives_via_Direct_3_Acylation_of_Indole/1380306
10.6084/m9.figshare.1380306.v3