%0 Journal Article %A Pan, Xianhua %A Bai, Shupei %A Yu, Wansheng %A Ding, Ding %A Zhao, Dongxian %A Liu, Feng %D 2015 %T Efficient Synthesis of 3-R-Boc-amino-4-(2,4,5-trifluorophenyl)butyric Acid %U https://tandf.figshare.com/articles/journal_contribution/Efficient_Synthesis_of_3_i_R_i_Boc_amino_4_2_4_5_trifluorophenyl_butyric_Acid/1380305 %R 10.6084/m9.figshare.1380305.v2 %2 https://ndownloader.figshare.com/files/2021484 %K chiral aziridine %K hydroxyl derivation %K methylthiomethyl group %K Efficient Synthesis %K acid segment %K ring opening %X

3-R-Boc-amino-4-(2,4,5-trifluorophenyl)butyric acid (9) was obtained from L-methionine in six steps with a total yield of 32%. The α-amino acid segment of L-methionine was transferred to chiral aziridine by amino protection, reduction, hydroxyl derivation, and cyclization. After ring opening of 2,4,5-trifluoro-phenyl magnesium bromide, the methylthiomethyl group was then hydrolyzed to β-amino alcohol and oxidized to the target β-amino acid.

%I Taylor & Francis