10.6084/m9.figshare.1380305.v2 Xianhua Pan Xianhua Pan Shupei Bai Shupei Bai Wansheng Yu Wansheng Yu Ding Ding Ding Ding Dongxian Zhao Dongxian Zhao Feng Liu Feng Liu Efficient Synthesis of 3-<i>R</i>-Boc-amino-4-(2,4,5-trifluorophenyl)butyric Acid Taylor & Francis Group 2015 chiral aziridine hydroxyl derivation methylthiomethyl group Efficient Synthesis acid segment ring opening 2015-05-05 18:53:32 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Efficient_Synthesis_of_3_i_R_i_Boc_amino_4_2_4_5_trifluorophenyl_butyric_Acid/1380305 <div><p></p><p>3-<i>R</i>-Boc-amino-4-(2,4,5-trifluorophenyl)butyric acid (<b>9</b>) was obtained from <i>L</i>-methionine in six steps with a total yield of 32%. The α-amino acid segment of <i>L</i>-methionine was transferred to chiral aziridine by amino protection, reduction, hydroxyl derivation, and cyclization. After ring opening of 2,4,5-trifluoro-phenyl magnesium bromide, the methylthiomethyl group was then hydrolyzed to β-amino alcohol and oxidized to the target β-amino acid.</p></div>