Multicomponent Domino Process for the Synthesis of Some Novel Benzo[<i>a</i>]chromenophenazine Fused Ring Systems Using H<sub>2</sub>SO<sub>4</sub>, Phosphotungstic Acid, and [NMP]H<sub>2</sub>PO<sub>4</sub>
M. Rajeswari
Garima Khanna
Ankita Chaudhary
Jitender M. Khurana
10.6084/m9.figshare.1378785.v2
https://tandf.figshare.com/articles/journal_contribution/Multicomponent_Domino_Process_for_the_Synthesis_of_Some_Novel_Benzo_i_a_i_chromenophenazine_Fused_Ring_Systems_Using_H_sub_2_sub_SO_sub_4_sub_Phosphotungstic_Acid_and_NMP_H_sub_2_sub_PO_sub_4_sub_/1378785
<div><p></p><p>Efficient, mild, and quantitative procedures for the synthesis of functionalized benzo[<i>c</i>]chromeno[2,3-<i>a</i>]phenazine derivatives by one-pot, four-component condensation of 2-hydroxynaphthalene-1,4-dione, 1,2-phenylenediamines, aromatic aldehydes, and cyclic 1,3-dicarbonyl compounds have been developed using catalytic amounts of H<sub>2</sub>SO<sub>4</sub> and phosphotungstic acid in EtOH/H<sub>2</sub>O (1:1) under reflux and also with [NMP]H<sub>2</sub>PO<sub>4</sub>, which acts as catalyst and medium at 80 °C. The reaction avoids tedious workup procedure due to the direct precipitation of products from the reaction medium. The present finding provides promising synthetic strategies for the synthesis of libraries with functional group diversity<i>.</i></p></div>
2015-05-05 18:53:32
phenylenediamine
fused
Multicomponent Domino Process
functionalized
efficient
compound
H 2SO
group diversity
benzo
dicarbonyl
H 2SO Phosphotungstic
strategy
hydroxynaphthalene
aldehyde
synthesis
etoh
condensation
catalyst
derivative
workup procedure
nmp
cyclic
reflux
reaction medium
Synthesi
phosphotungstic acid