Comparison of Normal Saline, Hypertonic Saline Albumin and Terlipressin plus Hypertonic Saline Albumin in an Infant Animal Model of Hypovolemic Shock
Javier Urbano
Rafael González
Jorge López
María J Solana
José M. Bellón
Marta Botrán
Ana García
Sarah N. Fernández
Jesús López-Herce
10.1371/journal.pone.0121678
https://plos.figshare.com/articles/dataset/_Comparison_of_Normal_Saline_Hypertonic_Saline_Albumin_and_Terlipressin_plus_Hypertonic_Saline_Albumin_in_an_Infant_Animal_Model_of_Hypovolemic_Shock_/1345718
<div><p>Introduction</p><p>In series of cases and animal models suffering hemorrhagic shock, the use of vasopressors has shown potential benefits regarding hemodynamics and tissue perfusion. Terlipressin is an analogue of vasopressin with a longer half-life that can be administered by bolus injection. We have previously observed that hypertonic albumin improves resuscitation following controlled hemorrhage in piglets. The aim of the present study was to analyze whether the treatment with the combination of terlipressin and hypertonic albumin can produce better hemodynamic and tissular perfusion parameters than normal saline or hypertonic albumin alone at early stages of hemorrhagic shock in an infant animal model.</p><p>Methods</p><p>Experimental, randomized animal study including 39 2-to-3-month-old piglets. Thirty minutes after controlled 30 ml/kg bleed, pigs were randomized to receive either normal saline (NS) 30 ml/kg (n = 13), 5% albumin plus 3% hypertonic saline (AHS) 15 ml/kg (n = 13) or single bolus of terlipressin 15 μg/kg i.v. plus 5% albumin plus 3% hypertonic saline 15 ml/kg (TAHS) (n = 13) over 30 minutes. Global hemodynamic and tissular perfusion parameters were compared.</p><p>Results</p><p>After controlled bleed a significant decrease of blood pressure, cardiac index, central venous saturation, carotid and peripheral blood flow, brain saturation and an increase of heart rate, gastric PCO<sub>2</sub> and lactate was observed. After treatment no significant differences in most hemodynamic (cardiac index, mean arterial pressure) and perfusion parameters (lactate, gastric PCO<sub>2</sub>, brain saturation, cutaneous blood flow) were observed between the three therapeutic groups. AHS and TAHS produced higher increase in stroke volume index and carotid blood flow than NS.</p><p>Conclusions</p><p>In this pediatric animal model of hypovolemic shock, albumin plus hypertonic saline with or without terlipressin achieved similar hemodynamics and perfusion parameters than twice the volume of NS. Addition of terlipressin did not produce better results than AHS.</p></div>
2015-03-20 04:04:08
terlipressin
TAHS
Infant Animal Model
saturation
perfusion parameters
stroke volume index
ahs
ml
hypertonic albumin
pco
infant animal model.MethodsExperimental
Hypertonic Saline Albumin
hemorrhagic shock
cutaneous blood flow
ns
carotid blood flow
saline
hemodynamic
randomized animal study
tissular perfusion parameters
Hypovolemic Shock IntroductionIn series