Antioxidative and anticarcinogenic activities of methylpheophorbide a, isolated from wheat grass (<i>Triticum aestivum</i> Linn.)
Priyabrata Das
Suvra Mandal
Sudeshna Gangopadhyay
Kalipada Das
Arpita Ghosh Mitra
Swati Dasgupta
Soma Mukhopadhyay
Ashis Mukhopadhyay
10.6084/m9.figshare.1339861.v2
https://tandf.figshare.com/articles/journal_contribution/Antioxidative_and_anticarcinogenic_activities_of_methylpheophorbide_a_isolated_from_wheat_grass_i_Triticum_aestivum_i_Linn_/1339861
<div><p>Methylphophorbide a (MPa) has been isolated from the ethanol extract of the wheat grass plant. Its antioxidative efficacy is evaluated by hydroxyl radical scavenging activities and reducing capacity which are significantly up regulated in comparison with aqueous extract of the plant. The compound shows iron-binding capacity where the Fe<sup>2+</sup> binds with MPa by two types of binding patterns with dissociation constants 157.17 and 27.89. It has antioxidative and cytotoxic effects on HeLa and Hep G2 cells. The cancerous cell survivability decreases with increasing concentration of MPa. These findings have provided evidence for the traditional use of the wheat grass plant in the treatment of cancers, oxidative stress and iron overloaded disorders.</p></div>
2015-03-18 14:00:15
anticarcinogenic activities
wheat grass
capacity
antioxidative efficacy
mpa
cytotoxic effects
Hep G 2 cells
cell survivability decreases
binding patterns
oxidative stress
wheat grass plant
dissociation constants 157.17