10.6084/m9.figshare.1339861.v2 Priyabrata Das Priyabrata Das Suvra Mandal Suvra Mandal Sudeshna Gangopadhyay Sudeshna Gangopadhyay Kalipada Das Kalipada Das Arpita Ghosh Mitra Arpita Ghosh Mitra Swati Dasgupta Swati Dasgupta Soma Mukhopadhyay Soma Mukhopadhyay Ashis Mukhopadhyay Ashis Mukhopadhyay Antioxidative and anticarcinogenic activities of methylpheophorbide a, isolated from wheat grass (<i>Triticum aestivum</i> Linn.) Taylor & Francis Group 2015 anticarcinogenic activities wheat grass capacity antioxidative efficacy mpa cytotoxic effects Hep G 2 cells cell survivability decreases binding patterns oxidative stress wheat grass plant dissociation constants 157.17 2015-03-18 14:00:15 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Antioxidative_and_anticarcinogenic_activities_of_methylpheophorbide_a_isolated_from_wheat_grass_i_Triticum_aestivum_i_Linn_/1339861 <div><p>Methylphophorbide a (MPa) has been isolated from the ethanol extract of the wheat grass plant. Its antioxidative efficacy is evaluated by hydroxyl radical scavenging activities and reducing capacity which are significantly up regulated in comparison with aqueous extract of the plant. The compound shows iron-binding capacity where the Fe<sup>2+</sup> binds with MPa by two types of binding patterns with dissociation constants 157.17 and 27.89. It has antioxidative and cytotoxic effects on HeLa and Hep G2 cells. The cancerous cell survivability decreases with increasing concentration of MPa. These findings have provided evidence for the traditional use of the wheat grass plant in the treatment of cancers, oxidative stress and iron overloaded disorders.</p></div>