10.1371/journal.pgen.1004925.g001
Pía Villanueva
Pía
Villanueva
Ron Nudel
Ron
Nudel
Alexander Hoischen
Alexander
Hoischen
María Angélica Fernández
María
Angélica Fernández
Nuala H. Simpson
Nuala
H. Simpson
Christian Gilissen
Christian
Gilissen
Rose H. Reader
Rose
H. Reader
Lillian Jara
Lillian
Jara
Maria Magdalena Echeverry
Maria
Magdalena Echeverry
Clyde Francks
Clyde
Francks
Gillian Baird
Gillian
Baird
Gina Conti-Ramsden
Gina
Conti-Ramsden
Anne O’Hare
Anne
O’Hare
Patrick F. Bolton
Patrick
F. Bolton
Elizabeth R. Hennessy
Elizabeth
R. Hennessy
Hernán Palomino
Hernán
Palomino
Luis Carvajal-Carmona
Luis
Carvajal-Carmona
Joris A. Veltman
Joris
A. Veltman
Jean-Baptiste Cazier
Jean-Baptiste
Cazier
Zulema De Barbieri
Zulema
De Barbieri
Simon E. Fisher
Simon
E. Fisher
Dianne F. Newbury
Dianne
F. Newbury
Pedigree showing direct lines of descent between founder brothers and children in Robinson Crusoe validation cohort.
Public Library of Science
2015
coding variants
South American populations
sequencing
individual
NFXL 1 gene
NFXL 1
Robinson Crusoe Island
Specific Language Impairment
Specific Language Impairment Children
150k
Robinson Crusoe population
Population Indicates NFXL 1 Variants Confer
117 UK SLI cases
2015-03-17 03:24:38
Figure
https://plos.figshare.com/articles/figure/_Pedigree_showing_direct_lines_of_descent_between_founder_brothers_and_children_in_Robinson_Crusoe_validation_cohort_/1338399
<p>Founder brothers are individuals on the second line of the pedigree. Individuals with language impairment are colored in black. Individuals with typical language are denoted in white. Individuals with unknown phenotype are shaded grey. Genotypes at rs144169475 are represented by small circles; blue circles represent homozygote reference allele, red circles represent variant carriers, grey circles represent unknown genotype. Note that each individual may be represented through multiple lines of descent and so might appear more than once on this diagram. Children are labelled according to affection status—SLI1 to SLI15 and TLD1 to TLD17. Cases whose exomes were sequenced are indicated by asterisks. Three children (1 affected, 2 unaffected, none of whom carried the rs144169475 variant) are not represented on this figure since they were related to alternative founder families. SLI15 is known to be related to one of the founder brothers but the exact line of descent is unknown.</p>