Synthesis of Novel Saccharide Hydrazones
Mihkel Ilisson
Kristjan Tomson
Anastasia Selyutina
Silver Türk
Uno Mäeorg
10.6084/m9.figshare.1314932.v2
https://tandf.figshare.com/articles/journal_contribution/Synthesis_of_Novel_Saccharide_Hydrazones/1314932
<div><p></p><p>Synthesis of important heterocyclic hydrazine derivatives N-aminopyrrolidine, N-aminopiperidine, and N-aminoazepane from hydrazine hydrate and dihalogenides were examined and optimized. These heterocyclic hydrazine derivatives were used in condensation reactions with six different monosaccharides to form corresponding hydrazones. Biological evaluations of these novel compounds, which are simple acyclic nucleoside analogs, were done. L-Arabinose N-aminoazepane hydrazone showed minor anti-HIV activity, giving a starting point for further structural modifications.</p></div>
2015-04-16 21:16:48
Condensation reactions
hydrazine hydrate
hydrazone
novel compounds
Novel Saccharide Hydrazones Synthesis
heterocyclic hydrazine derivatives
Biological Evaluations
acyclic nucleoside analogs