L. Álvarez, Ángel Habtemariam, Solomon Parra, Francisco Inhibitory effects of lupene-derived pentacyclic triterpenoids from <i>Bursera simaruba</i> on HSV-1 and HSV-2 <i>in vitro</i> replication <div><p>The cytotoxicity and antiviral properties of <i>Bursera simaruba</i> against herpes simplex viruses (HSV-1 and HSV-2) were investigated through a bioactivity-guided isolation protocol. The plant material was fractionated using solvent-solvent partitioning, size-exclusion and thin-layer chromatography. The antiviral compounds present in the most active fractions were identified by means of LC-MS and NMR. Three different methods were compared during the evaluation of antiviral activity of samples. Four lupene-related pentacyclic triterpenes were found to be responsible for the anti-herpesvirus effects of <i>B. simaruba</i> and were isolated from this species for the first time. The selective indexes (SI) of <i>B. simaruba</i>-derived samples ranged from 7.7 to 201.9.</p></div> sample;Bursera simaruba;hsv;pentacyclic;nmr;herpes simplex viruses;si 2015-10-08
    https://tandf.figshare.com/articles/journal_contribution/Inhibitory_effects_of_lupene_derived_pentacyclic_triterpenoids_from_i_Bursera_simaruba_i_on_HSV_1_and_HSV_2_i_in_vitro_i_replication/1306941
10.6084/m9.figshare.1306941.v2