S. Said, Madhukar Chinchansure, Ashish A. Nawale, Laxman Durge, Ankita Wadhwani, Ashish S. Kulkarni, Smita Sarkar, Dhiman Joshi, Swati P. A new butenolide cinnamate and other biological active chemical constituents from <i>Polygonum glabrum</i> <div><p>Phytochemical investigation of the methanol extract of the aerial parts of <i>Polygonum glabrum</i> afforded one new natural product ( − )-2-methoxy-2-butenolide-3-cinnamate (<b>1</b>) along with six known compounds, β-hydroxyfriedalanol (<b>2</b>), 3-hydroxy-5-methoxystilbene (<b>3</b>), ( − ) pinocembrin (<b>4</b>), sitosterol-(6′-<i>O</i>-palmitoyl)-3-<i>O</i>-β-d-glucopyranoside (<b>5</b>), ( − ) pinocembrin-5-methyl ether (<b>6</b>) and sitosterol-3-<i>O</i>-β-d-glucopyranoside (<b>7</b>). Compound <b>1</b> showed promising <i>in vitro</i> anti-HIV-1 activity against primary isolates HIV-1<sub>UG070</sub> (X4, subtype D) and HIV-1<sub>VB59</sub> (R5, subtype C) assayed using TZM-bl cell line with IC<sub>50</sub> in the range of 15.68–22.43 μg/mL. The extract showed TI in the range of 19.19–27.37 with IC<sub>50</sub> in the range of 10.90–15.55 μg/mL. Compounds <b>1</b>, <b>3</b> and <b>4</b> exhibited <i>in vitro</i> anti-mycobacterium activity against <i>Mycobacterium tuberculosis</i> H37Ra with IC<sub>50</sub> values of 1.43, 3.33 and 1.11 μg/mL in dormant phase and 2.27, 3.33 and 1.21 μg/mL in active phase, respectively. Compound <b>4</b> was found to be the most active antiproliferative with IC<sub>50</sub> values of 1.88–11.00 μg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines.</p></div> thp;phase;Polygonum glabrum Phytochemical investigation;pinocembrin;subtype;compound;IC 50 values;sitosterol;3.33;IC 50;Mycobacterium tuberculosis H 37Ra;HIV;MCF 7 cell lines;ti 2015-10-08
    https://tandf.figshare.com/articles/journal_contribution/A_new_butenolide_cinnamate_and_other_biological_active_chemical_constituents_from_i_Polygonum_glabrum_i_/1300047
10.6084/m9.figshare.1300047.v2