10.6084/m9.figshare.1300047.v2
Madhukar S. Said
Madhukar
S. Said
Ashish A. Chinchansure
Ashish A.
Chinchansure
Laxman Nawale
Laxman
Nawale
Ankita Durge
Ankita
Durge
Ashish Wadhwani
Ashish
Wadhwani
Smita S. Kulkarni
Smita
S. Kulkarni
Dhiman Sarkar
Dhiman
Sarkar
Swati P. Joshi
Swati P.
Joshi
A new butenolide cinnamate and other biological active chemical constituents from <i>Polygonum glabrum</i>
Taylor & Francis Group
2015
thp
phase
Polygonum glabrum Phytochemical investigation
pinocembrin
subtype
compound
IC 50 values
sitosterol
3.33
IC 50
Mycobacterium tuberculosis H 37Ra
HIV
MCF 7 cell lines
ti
2015-10-08 16:04:43
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/A_new_butenolide_cinnamate_and_other_biological_active_chemical_constituents_from_i_Polygonum_glabrum_i_/1300047
<div><p>Phytochemical investigation of the methanol extract of the aerial parts of <i>Polygonum glabrum</i> afforded one new natural product ( − )-2-methoxy-2-butenolide-3-cinnamate (<b>1</b>) along with six known compounds, β-hydroxyfriedalanol (<b>2</b>), 3-hydroxy-5-methoxystilbene (<b>3</b>), ( − ) pinocembrin (<b>4</b>), sitosterol-(6′-<i>O</i>-palmitoyl)-3-<i>O</i>-β-d-glucopyranoside (<b>5</b>), ( − ) pinocembrin-5-methyl ether (<b>6</b>) and sitosterol-3-<i>O</i>-β-d-glucopyranoside (<b>7</b>). Compound <b>1</b> showed promising <i>in vitro</i> anti-HIV-1 activity against primary isolates HIV-1<sub>UG070</sub> (X4, subtype D) and HIV-1<sub>VB59</sub> (R5, subtype C) assayed using TZM-bl cell line with IC<sub>50</sub> in the range of 15.68–22.43 μg/mL. The extract showed TI in the range of 19.19–27.37 with IC<sub>50</sub> in the range of 10.90–15.55 μg/mL. Compounds <b>1</b>, <b>3</b> and <b>4</b> exhibited <i>in vitro</i> anti-mycobacterium activity against <i>Mycobacterium tuberculosis</i> H37Ra with IC<sub>50</sub> values of 1.43, 3.33 and 1.11 μg/mL in dormant phase and 2.27, 3.33 and 1.21 μg/mL in active phase, respectively. Compound <b>4</b> was found to be the most active antiproliferative with IC<sub>50</sub> values of 1.88–11.00 μg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines.</p></div>