L. Baker, Christopher Kajita, Shimpei Walker, Michael L. Saxl, Ruth Raghupathy, Narayanan Choi, Kwangbom M. Petkov, Petko Paigen, Kenneth Model for the evolution of <i>Prdm9</i> alleles and hotspot erosion. <p>(A) Predicted timeline for the origin of <i>Prdm9</i> alleles based on SNP frequency found at hotspots comparing B6 and CAST to SPRET. PRDM9<sup>Cst</sup> hotspots show an increase in SNPs in the B6 background, suggesting this allele was active in a shared lineage between <i>M.m. castaneus</i> and <i>M.m. domesticus</i>. PRDM9<sup>Dom2</sup> hotspots do not have increased SNPs in the CAST background suggesting this allele was never active in <i>M.m. castaneus</i>. (B) The PRDM9/hotspot lifecycle. Evolutionary erosion driven by biased PRDM9 initiation of recombination decreases hotspot activity over time at many hotspots in parallel. Mutation of <i>Prdm9</i> creates a new binding domain subsequently shifting the genome-wide position of hotspots.</p> PRDM 9 binding;hotspot;Prdm 9Cst allele;PRDM 9Cst binding;Meiotic Recombination Meiotic recombination;PRDM 9 Drives Evolutionary Erosion;Zinc Finger Protein;Prdm 9 allele;histone methyltransferase activity;PRDM 9 drives;dna;DSB repair mechanism;Mus musculus subspecies;M.m;Prdm 9Cst 2015-01-08
    https://plos.figshare.com/articles/figure/_Model_for_the_evolution_of_Prdm9_alleles_and_hotspot_erosion_/1286608
10.1371/journal.pgen.1004916.g007