10.1371/journal.pone.0114691.g005
Kristof Moonens
Kristof
Moonens
Maia De Kerpel
Maia
De Kerpel
Annelies Coddens
Annelies
Coddens
Eric Cox
Eric
Cox
Els Pardon
Els
Pardon
Han Remaut
Han
Remaut
Henri De Greve
Henri
De Greve
Conformational change induced inhibition of adhesion by nanobodies NbFedF6 and NbFedF7.
Public Library of Science
2014
Protective treatments
farming industry
attachment
Nanobody Mediated Inhibition
FedF surface
fimbriated pathogens
piglet enterocytes
blood group antigen receptors
membrane context
nanobodie
lectin domain
adhesin domain
F 18 fimbrial adhesin FedF
FedF lectin domain
F 18 fimbriated E
coli bacteria
CDR 3 region
F 18 fimbriated bacteria
adherence assay
binding site
blood group antigen receptor
F 18 Fimbriae
edema disease
production losses
loop
2014-12-11 03:04:10
Figure
https://plos.figshare.com/articles/figure/_Conformational_change_induced_inhibition_of_adhesion_by_nanobodies_NbFedF6_and_NbFedF7_/1268302
<p>Superimposition of the FedF-blood group A type 1 hexasaccharide (A6-1) co-complex structure (colored yellow) with the co-complex structures of FedF-NbFedF6 (<b>A</b>) and FedF-NbFedF7 (<b>B</b>) (β-strands, α-helices and loops are colored respectively cyan, red and grey). Both NbFedF6 and NbFedF7 induce a conformational change in the D″-E loop that is protruding from the FedF surface thereby reorienting the loop outwards from the A6-1 binding site. A6-1 is depicted in stick model with carbon, oxygen and nitrogen atoms colored respectively purple, red and blue.</p>