%0 Figure %A Yadav, Puja %A Harcy, Victoria %A Lucas Argueso, Juan %A Dominska, Margaret %A Jinks-Robertson, Sue %A Kim, Nayun %D 2014 %T The effect of replication direction on the gene conversion rate. %U https://plos.figshare.com/articles/figure/_The_effect_of_replication_direction_on_the_gene_conversion_rate_/1259891 %R 10.1371/journal.pgen.1004839.g006 %2 https://ndownloader.figshare.com/files/1821129 %K G 4 motif %K G 4 DNA %K Suppressing Genome Instability %K immunoglobulin switch Mu %K yeast chromosome V %K S μ sequence %K iii %K genome instability %K genome rearrangements %X

A. A schematic representation of the gene conversion assay. The pTET-lys2-GTOP cassette (indicated by the hashed box) is located in “Head-on” orientation relative to ARS306. In the ars306Δ strain, the closest origin of replication is ARS305 from which replication proceeds in a co-directional orientation with the transcription from pTET. The distances (in kb) are approximate and not to scale. B. The rates of gene conversion at pTET-lys2-GTOP or –GBTM cassette. Transcription and replication are in the “Head-on” orientation when ARS306 (gray bar) is present and in the “Co-directional” orientation in ars306Δ strains (hashed bar). The 95% confidence intervals are indicated by the error bars.

%I PLOS Genetics