Lipoxygenase inhibitory activity of <i>Cuspidaria pulchra</i> and isolated compounds A. AlvarengaTavane S. BertanhaCamila F. de OliveiraPollyanna TavaresDenise C. M.M. GimenezValéria L.A. SilvaMárcio R. CunhaWilson H. JanuárioAna M. PaulettiPatrícia 2015 <div><p>This work evaluated the <i>in vitro</i> inhibitory activity of the crude ethanolic extract from the aerial parts of <i>Cuspidaria pulchra</i> (Cham.) L.G. Lohmann against 15-lipoxygenase (15-LOX). The bioassay-guided fractionation of the <i>n</i>-butanol fraction, which displayed the highest activity, led to the isolation of three compounds: caffeoylcalleryanin (<b>1</b>), verbascoside (<b>2</b>) and 6-hydroxyluteolin-7-<i>O</i>-β-glucoside (<b>3</b>). Assessment of the ability of the isolated compounds to inhibit 15-LOX revealed that compounds <b>1</b>, <b>2</b> and <b>3</b> exerted strong 15-LOX inhibitory activity; IC<sub>50</sub> values were 1.59, 1.76 and 2.35 μM respectively. The XTT assay showed that none of the isolated compounds seemed to be significantly toxic.</p></div>