10.6084/m9.figshare.1252136.v3
Chinedu P. Anokwuru
Chinedu
P. Anokwuru
Annamaria Sinisi
Annamaria
Sinisi
Amidou Samie
Amidou
Samie
Orazio Taglialatela-Scafati
Orazio
Taglialatela-Scafati
Antibacterial and antioxidant constituents of <i>Acalypha wilkesiana</i>
Taylor & Francis Group
2015
Acalypha wilkesiana
corilagin
exhibit antioxidant activity
dpph
compound
quadrangularic acid M
ic
metabolite
2015-06-16 15:01:38
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Antibacterial_and_antioxidant_constituents_of_i_Acalypha_wilkesiana_i_/1252136
<div><p>This study was aimed at characterising the secondary metabolites responsible for antibacterial and antioxidant activities of <i>Acalypha wilkesiana</i>. Purification of the defatted methanol leaves extract was guided by the DPPH free radical scavenging assay as well as by evaluation of the antibacterial activity against four bacterial strains. As a result, geraniin, corilagin, quadrangularic acid M and shikimic acid were purified and isolated. Shikimic acid, reported for the first time from this plant, proved to be the major metabolite of the extract. All the four isolated compounds showed bactericidal activity against extended spectrum beta-lactamase-producing <i>Klebsiella pneumoniae</i> (700603), while corilagin was the single compound to exhibit antioxidant activity (IC<sub>50</sub> 53 μg/mL).</p></div>