Illustration of model input.
Gleb Kichaev
Wen-Yun Yang
Sara Lindstrom
Farhad Hormozdiari
Eleazar Eskin
Alkes L. Price
Peter Kraft
Bogdan Pasaniuc
10.1371/journal.pgen.1004722.g001
https://plos.figshare.com/articles/figure/_Illustration_of_model_input_/1223773
<p>PAINTOR is a statistical model for incorporating functional annotations on top of association statistics to ascribe probabilistic confidence of causality to the SNPs at the loci. Depicted here are two loci with functional annotations from three different cell lines/tissues and three different classes. Causal variants are enriched within the green annotation class while depleted from others. PAINTOR is designed to upweight (with probability mass) SNPs residing in the green annotation while down-weighting SNPs residing in the red annotation.</p>
2014-10-30 04:03:30
snp
blood lipids traits
estimate causality probabilities
risk loci
Prioritize Causal Variants
summary association statistics
1000 Genomes data
genomic annotation data
variant
Integrating Functional Data