Illustration of model input. Gleb Kichaev Wen-Yun Yang Sara Lindstrom Farhad Hormozdiari Eleazar Eskin Alkes L. Price Peter Kraft Bogdan Pasaniuc 10.1371/journal.pgen.1004722.g001 https://plos.figshare.com/articles/figure/_Illustration_of_model_input_/1223773 <p>PAINTOR is a statistical model for incorporating functional annotations on top of association statistics to ascribe probabilistic confidence of causality to the SNPs at the loci. Depicted here are two loci with functional annotations from three different cell lines/tissues and three different classes. Causal variants are enriched within the green annotation class while depleted from others. PAINTOR is designed to upweight (with probability mass) SNPs residing in the green annotation while down-weighting SNPs residing in the red annotation.</p> 2014-10-30 04:03:30 snp blood lipids traits estimate causality probabilities risk loci Prioritize Causal Variants summary association statistics 1000 Genomes data genomic annotation data variant Integrating Functional Data