10.1371/journal.pgen.1004718.g004
Peter Bou Dib
Peter
Bou Dib
Bettina Gnägi
Bettina
Gnägi
Fiona Daly
Fiona
Daly
Virginie Sabado
Virginie
Sabado
Damla Tas
Damla
Tas
Dominique A. Glauser
Dominique
A. Glauser
Peter Meister
Peter
Meister
Emi Nagoshi
Emi
Nagoshi
Partial loss of <i>Fer2</i> expression impairs the viability of PAM neurons in aging flies.
Public Library of Science
2014
p 48 Homologs
DA neurons
PAM neuron degeneration
p 48 homologs share
neurodegenerative movement disorder
Drosophila p 48 homolog
pd
ros
Fer 2 expression
DA neuron survival
Reactive oxygen species
Protecting Dopaminergic Neurons
oxidative stress
oxidative stress challenge upregulates Fer 2 expression
Oxidative Stress Parkinson
2014-10-23 17:16:41
Figure
https://plos.figshare.com/articles/figure/_Partial_loss_of_Fer2_expression_impairs_the_viability_of_PAM_neurons_in_aging_flies_/1220341
<p>Quantification of PAM neurons in the flies of different genotypes detected by anti-TH staining at indicated ages. Box boundaries are the 25th and 75th percentiles, the horizontal line across the box is the median, and the whiskers are the lowest and highest values that are not outliers. The open circles represent outliers and closed circles are extreme cases. *p<0.05, **p<0.01, *** p<0.001, comparing <i>Fer2<sup>2</sup>/+</i> and <i>Fer2<sup>2</sup></i> at the same age (A), or between <i>miR-Fer2-N</i> and <i>miR-Fer2-4/</i>-<i>5</i> at the same age (B-D). Sample sizes are indicated in the <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004718#s4" target="_blank">Materials and Methods</a>. (A) PAM neurons in <i>Fer2<sup>2</sup></i> and the control (<i>Fer2<sup>2</sup>/+</i>). (B) Constitutive expression of <i>miR Fer2s</i> by <i>Fer2-GAL4.</i> (C) Constitutive expression of <i>miR Fer2s</i> by <i>R58E02-GAL4</i>. (D) Adult-specific <i>Fer2</i> knockdown and the control. <i>Fer2-GAL4</i>, <i>tub-gal80<sup>ts</sup></i>: control without UAS-transgene.</p>