Zhang, Yongmei Mao, Richeng Yan, Ran Cai, Dawei Zhang, Yijun Zhu, Haoxiang Kang, Yaoyue Liu, Hongyan Wang, Jinyu Qin, Yanli Huang, Yuxian Guo, Haitao Zhang, Jiming HBV cccDNA CpG island III methylation is associated with serum HBsAg level. <p>(A) Correlation between serum HBsAg titers and cccDNA CpG island III methylation in patients with chronic HBV infection (r2 = 0.32, <i>P</i><0.05). (B) The density of CpG island III methylation were significantly higher in patients with low serum HBsAg titer (Log10HBsAg<4) compared to those with high HBsAg level (Log10HBsAg≥4). Dots and squares represent single patient measurement. The median value is indicated with a long line.</p> serum HBsAg titers;serum HBV DNA;Hepatitis B virus;iii;CpG island methylation;core DNA replication;Hepatitis B Virus Covalently;CpG island II methylation;cccDNA CpG methylation status;liver fibrosis stage;CpG methylation;HBV cccDNA transcription;hepatitis B patients 2014-10-22
    https://plos.figshare.com/articles/figure/_HBV_cccDNA_CpG_island_III_methylation_is_associated_with_serum_HBsAg_level_/1212366
10.1371/journal.pone.0110442.g002