10.1371/journal.pone.0110085.g001 Ariel Erijman Ariel Erijman Eran Rosenthal Eran Rosenthal Julia M. Shifman Julia M. Shifman Dependence of Kd on various single biophysical features. Public Library of Science 2014 binding affinities PPI binding affinities Structure Defines Affinity nmr interaction binding affinity novel binding partners 2014-10-16 04:24:31 Figure https://plos.figshare.com/articles/figure/_Dependence_of_Kd_on_various_single_biophysical_features_/1207521 <p>(A) Change in the accessible interface surface area (ASA); (B) ΔASA normalized to the total interface area; (C) percent of non-polar change in the accessible surface area; (D) the total number of interfacial H bonds, (E) the number of intermolecular interfacial H bonds, (F) the number of intra-molecular H bonds; (G) Van der Waals energy; (H) volume of cavities; (I) number of hotspots; (J) electrostatic columbic energy; (K) RMSD between bound and unbound structures for interface Cαs; (L) percentage of rotamers that do not change conformation upon binding. Each point represents one PDB file in the database and the line corresponds to a linear fit to all data points in the database.</p>