%0 Journal Article %A Dong, Fang %A Liu, Jian-Quan %A Wang, Xiang-Shan %D 2020 %T CuBr-Catalyzed α‑Arylation and Aerobic Oxidative Dehydrogenative C–N Coupling for the Synthesis of Spiro[cyclohexane-1,12′-isoindolo[1,2‑b]quinazolin]-10′-one Derivatives %U https://acs.figshare.com/articles/journal_contribution/CuBr-Catalyzed_Arylation_and_Aerobic_Oxidative_Dehydrogenative_C_N_Coupling_for_the_Synthesis_of_Spiro_cyclohexane-1_12_-isoindolo_1_2_i_b_i_quinazolin_-10_-one_Derivatives/12049179 %R 10.1021/acs.orglett.0c00497.s001 %2 https://ndownloader.figshare.com/files/22142649 %K quinazolin %K oxidant %K Spiro %K Aerobic %K bond formation %K Derivative %K Arylation %K spiro %K copper-catalyzed approach %K carbonyl %K Oxidative %K Synthesi %K α- arylation %K oxidative dehydrogenation %K nitrogen-substituted quaternary carbon center %K O 2 %K CuBr-Catalyzed %K Dehydrogenative %K domino method %K synthesis %X A copper-catalyzed approach was disclosed for C­(sp3)–C­(sp2) bond formation via an α-arylation of carbonyl, and the subsequent oxidative dehydrogenation coupling occurred to form a C­(sp3)–N bond, wherein O2 served as a green oxidant. This protocol provided a domino method for the synthesis of spiro­[cyclohexane-1,12′-isoindolo­[1,2-b]­quinazolin]-10′-ones containing a nitrogen-substituted quaternary carbon center. %I ACS Publications