%0 Journal Article
%A Dong, Fang
%A Liu, Jian-Quan
%A Wang, Xiang-Shan
%D 2020
%T CuBr-Catalyzed α‑Arylation and Aerobic
Oxidative Dehydrogenative C–N Coupling for the Synthesis of
Spiro[cyclohexane-1,12′-isoindolo[1,2‑b]quinazolin]-10′-one Derivatives
%U https://acs.figshare.com/articles/journal_contribution/CuBr-Catalyzed_Arylation_and_Aerobic_Oxidative_Dehydrogenative_C_N_Coupling_for_the_Synthesis_of_Spiro_cyclohexane-1_12_-isoindolo_1_2_i_b_i_quinazolin_-10_-one_Derivatives/12049179
%R 10.1021/acs.orglett.0c00497.s001
%2 https://ndownloader.figshare.com/files/22142649
%K quinazolin
%K oxidant
%K Spiro
%K Aerobic
%K bond formation
%K Derivative
%K Arylation
%K spiro
%K copper-catalyzed approach
%K carbonyl
%K Oxidative
%K Synthesi
%K α- arylation
%K oxidative dehydrogenation
%K nitrogen-substituted quaternary carbon center
%K O 2
%K CuBr-Catalyzed
%K Dehydrogenative
%K domino method
%K synthesis
%X A copper-catalyzed
approach was disclosed for C(sp3)–C(sp2) bond formation via an α-arylation of carbonyl, and
the subsequent oxidative dehydrogenation coupling occurred to form
a C(sp3)–N bond, wherein O2 served as
a green oxidant. This protocol provided a domino method for the synthesis
of spiro[cyclohexane-1,12′-isoindolo[1,2-b]quinazolin]-10′-ones containing a nitrogen-substituted quaternary
carbon center.
%I ACS Publications