Warta, Rolf Theile, Dirk Mogler, Carolin Herpel, Esther Grabe, Niels Lahrmann, Bernd K. Plinkert, Peter Herold-Mende, Christel Weiss, Johanna Dyckhoff, Gerhard mRNA expression of drug transporters in HNSCC. <p>(A) Determination of mRNA expression levels of drug transporters by qRT-PCR in a study sample of therapy naïve stage IVa HNSCC tumors (n = 40, grey boxes) and normal control samples (n = 14, white boxes) (relative mRNA expression normalized to the lowest value). (B) External validation by HNSCC RNAseq mRNA expression data derived from the ‘The Cancer Genome Atlas’ (TCGA) consortium. Comparison of normalized counts of paired tumor (n = 37, grey boxes) and adjacent noncancerous normal tissue (n = 37, white boxes). Whisker indicates 5–95 percentile; Mann-Whitney U test; **, p<0.01; ***, p<0.001.</p> drug efflux transporters;ABCG 2;Stage IV Head;Cancer Genome Atlas database;survival;mrp;ïve stage IV head;os;copper transporter ATP 7b mRNA expression;transcription polymerase chain reaction;bcrp;Analyzing mRNA expression levels;31A;Neck Squamous Cell Carcinoma Drug transporters;abcc;tma;drug transporters;Drug Transporter Expression;High ABCB 1 mRNA tumor expression;hnscc;slc;Protein expression;pfs 2014-10-02
    https://plos.figshare.com/articles/figure/_mRNA_expression_of_drug_transporters_in_HNSCC_/1192125
10.1371/journal.pone.0108908.g001