A pharmacophore of ebola active compounds
Sean Ekins
10.6084/m9.figshare.1190787.v1
https://figshare.com/articles/journal_contribution/A_pharmacophore_of_ebola_active_compounds/1190787
<p>Two 2013 papers yielded 4 FDA compounds active vs Ebola virus in vitro and in vivo. These were used to build a pharmacophore and virtually screen libraries.</p>
<p>Estradiol does not have the basic nitrogen common to the 4 active compounds but Madrid showed it was active in vitro but not against viral replication.</p>
2014-10-02 14:14:20
ebola
pharmacophore
FDA approved drugs
Cheminformatics
Infectious Diseases