L. Nemeth, Christina R. Glasper, Erica S. Harrell, Constance A. Malviya, Sanjana S. Otis, Jeffrey N. Neigh, Gretchen Depressive- and anxiety-like behaviors were measured in WT and HIV-1 tg rats receiving daily oral dosing of meloxicam. <p><i>A,B</i>) In the Porsolt forced swim test, meloxicam treated WT and HIV-1 tg rats showed similar latencies to first float (<i>p</i>>0.05); however, HIV-1 tg rats spent more time immobile compared to WT controls (*<i>p</i><0.05). <i>C,D</i>) Similarly, in the social interaction test, meloxicam treated WT and HIV-1 tg rats showed no differences in their time to approach a stimulus rat (<i>p</i>>0.05); however, overall, meloxicam-treated HIV-1 tg rats spend less time interacting (*<i>p</i><0.05). <i>E,F</i>) In the open field test, meloxicam treated HIV-1 tg rats showed no differences in overall locomotion (<i>p</i>>0.05), but did show a significant decrease in distance traveled in the center of the open field, as compared to WT rats (*<i>p</i><0.05). Data are presented as mean ± SEM.</p> Meloxicam Blocks Neuroinflammation;drug abuse behaviors;haart;hippocampal cell proliferation;hippocampu;expression;cox;monocyte chemotactic protein;adolescent HIV;Daily meloxicam treatments 2014-10-01
    https://plos.figshare.com/articles/figure/_Depressive_and_anxiety_like_behaviors_were_measured_in_WT_and_HIV_1_tg_rats_receiving_daily_oral_dosing_of_meloxicam_/1189618
10.1371/journal.pone.0108399.g004