%0 Journal Article
%A Jiao, Wei-Hua
%A Xu, Qi-Hang
%A Ge, Guang-Bo
%A Shang, Ru-Yi
%A Zhu, Hong-Rui
%A Liu, Hong-Yan
%A Cui, Jie
%A Sun, Fan
%A Lin, Hou-Wen
%D 2020
%T Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic
Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus
flavipes 164013
%U https://acs.figshare.com/articles/journal_contribution/Flavipesides_A_C_PKS-NRPS_Hybrids_as_Pancreatic_Lipase_Inhibitors_from_a_Marine_Sponge_Symbiotic_Fungus_i_Aspergillus_flavipes_i_164013/11855658
%R 10.1021/acs.orglett.0c00150.s001
%2 https://ndownloader.figshare.com/files/21728613
%K spectroscopic data analysis
%K Hybrid
%K strain
%K configuration
%K Pancreatic Lipase Inhibitors
%K Flavipeside
%K Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013
%K ECD
%K IC 50 values
%K pancreatic lipase
%K flavipeside
%K chlorinated PKS-NRPS
%K metabolite
%K fungus Aspergillus flavipes 164013.
%K PL
%K marine sponge
%K single-crystal X-ray diffraction
%X Three
unusual chlorinated PKS-NRPS hybrid metabolites, flavipesides
A–C (1–3), were isolated from
a strain of marine sponge symbiotic fungus Aspergillus flavipes 164013. Their structures were determined by spectroscopic data analysis,
and absolute configurations were assigned by single-crystal X-ray
diffraction with ECD spectral analysis. Flavipesides A–C showed
potent pancreatic lipase (PL) inhibitory activity with IC50 values of 0.07–0.23 μM.
%I ACS Publications