%0 Journal Article %A Jiao, Wei-Hua %A Xu, Qi-Hang %A Ge, Guang-Bo %A Shang, Ru-Yi %A Zhu, Hong-Rui %A Liu, Hong-Yan %A Cui, Jie %A Sun, Fan %A Lin, Hou-Wen %D 2020 %T Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013 %U https://acs.figshare.com/articles/journal_contribution/Flavipesides_A_C_PKS-NRPS_Hybrids_as_Pancreatic_Lipase_Inhibitors_from_a_Marine_Sponge_Symbiotic_Fungus_i_Aspergillus_flavipes_i_164013/11855658 %R 10.1021/acs.orglett.0c00150.s001 %2 https://ndownloader.figshare.com/files/21728613 %K spectroscopic data analysis %K Hybrid %K strain %K configuration %K Pancreatic Lipase Inhibitors %K Flavipeside %K Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013 %K ECD %K IC 50 values %K pancreatic lipase %K flavipeside %K chlorinated PKS-NRPS %K metabolite %K fungus Aspergillus flavipes 164013. %K PL %K marine sponge %K single-crystal X-ray diffraction %X Three unusual chlorinated PKS-NRPS hybrid metabolites, flavipesides A–C (13), were isolated from a strain of marine sponge symbiotic fungus Aspergillus flavipes 164013. Their structures were determined by spectroscopic data analysis, and absolute configurations were assigned by single-crystal X-ray diffraction with ECD spectral analysis. Flavipesides A–C showed potent pancreatic lipase (PL) inhibitory activity with IC50 values of 0.07–0.23 μM. %I ACS Publications