TY - DATA T1 - Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure–activity relationships PY - 2014/10/30 AU - Siau Hui Mah AU - Gwendoline Cheng Lian Ee AU - Soek Sin Teh AU - Mohd Aspollah Sukari UR - https://tandf.figshare.com/articles/journal_contribution/_i_Calophyllum_inophyllum_i_and_i_Calophyllum_soulattri_i_source_of_anti_proliferative_xanthones_and_their_structure_activity_relationships/1172166 DO - 10.6084/m9.figshare.1172166.v2 L4 - https://ndownloader.figshare.com/files/1678907 KW - GC KW - prenyl substituent groups KW - xanthone KW - mtt KW - uv KW - 2 D NMR KW - relationship KW - Calophyllum inophyllum KW - cancer cell lines KW - Calophyllum soulattri source KW - ir N2 - Extensive chromatographic isolation and purification of the extracts of the stem bark of Calophyllum inophyllum and Calophyllum soulattri have resulted in 11 xanthones. C. inophyllum gave inophinnin (1), inophinone (2), pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7) and 4-hydroxyxanthone (8), while C. soulattri afforded soulattrin (3), phylattrin (4), caloxanthone C (9), brasixanthone B (10) and trapezifolixanthone (11). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D NMR, GC–MS, IR and UV. Cytotoxicity screening (MTT assay) carried out in vitro on all the xanthones using five human cancer cell lines indicated good activities for some of these xanthones. The structure–activity relationship study revealed that the inhibitory activities exhibited by these xanthone derivatives to be closely related to the existence and nature of the pyrano and the prenyl substituent groups on their skeleton. ER -