10.6084/m9.figshare.1172164.v2
Chitturi Bhujanga Rao
Chitturi Bhujanga
Rao
Dokuburra Chanti Babu
Dokuburra
Chanti Babu
Tatipamula Vinay Bharadwaj
Tatipamula
Vinay Bharadwaj
Dudem Srikanth
Dudem
Srikanth
Kalivendi Shasi Vardhan
Kalivendi
Shasi Vardhan
Tuniki Venugopal Raju
Tuniki
Venugopal Raju
Richard A. Bunce
Richard A.
Bunce
Yenamandra Venkateswarlu
Yenamandra
Venkateswarlu
Isolation, structural assignment and synthesis of (<i>S</i><i>E</i>)-2-methyloctyl 3-(4-methoxyphenyl) propenoate from the marine soft coral <i>Sarcophyton ehrenbergi</i>
Taylor & Francis Group
2014
du
synthesis
marine
Sarcophyton ehrenbergi
mcf
se
2014-10-30 11:54:39
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Isolation_structural_assignment_and_synthesis_of_i_S_i_i_E_i_2_methyloctyl_3_4_methoxyphenyl_propenoate_from_the_marine_soft_coral_i_Sarcophyton_ehrenbergi_i_/1172164
<div><p>A new metabolite <b>1</b> has been isolated from the marine soft coral <i>Sarcophyton ehrenbergi</i> along with two known diterpenoids <b>2</b> and <b>3</b> and cholesterol <b>4</b>. The structure of <b>1</b> was determined by means of detailed spectroscopic analysis and unambiguously confirmed to have the <i>S</i> configuration by the synthesis of both enantiomers using 4-benzyl-2-oxazolidinone auxiliaries. (<i>S</i>)- and (<i>R</i>)-<b>1</b>, <b>3</b> and some of the synthetic intermediates were evaluated for cytotoxic activity against human lung cancer (A549), prostate cancer (DU145), cervical cancer (HeLa) and breast cancer (MCF-7) cell lines in an <i>in vitro</i> bioassay.</p></div>