10.1371/journal.pone.0106225.g005
Yankun Duan
Yankun
Duan
Lin Chen
Lin
Chen
Yongheng Chen
Yongheng
Chen
Xue-gong Fan
Xue-gong
Fan
Structure comparison of c-Src and JAK1 structures.
Public Library of Science
2014
van der Waals contacts
janus kinase inhibitor
Cancer Drug Ruxolitinib
JAK 1
Ruxolitinib binding
JAK 1 structure
2014-09-08 03:17:48
Figure
https://plos.figshare.com/articles/figure/_Structure_comparison_of_c_Src_and_JAK1_structures_/1165096
<p>(A) c-Src kinase domain (this work) is superimposed with JAK1 kinase domain (pdb: 3EYG) using the Ca atoms of kinase domain as the reference. c-Src is shown yellow, while JAK1 is shown in magenta. (B) Predicted c-Src ligand-binding pocket is shown in grey dots. (C) Predicted JAK1 ligand-binding pocket is shown in grey dots. Ligand-binding pocket is predicted using POCASA<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106225#pone.0106225-Yu1" target="_blank">[30]</a>.</p>