The minR reporter is repressed by Wnt signaling in circulating larval hemocytes. Chen U. Zhang Timothy A. Blauwkamp Peter E. Burby Ken M. Cadigan 10.1371/journal.pgen.1004509.g010 https://plos.figshare.com/articles/figure/_The_minR_reporter_is_repressed_by_Wnt_signaling_in_circulating_larval_hemocytes_/1147827 <p>(<b>A–I</b>) Micrographs of mid 3<sup>rd</sup> instar larval (∼88–96 AEL) circulating hemocyte smears from strains containing the minR reporter, P[He-Gal4] and P[UAS-GFP] and either + (A–C), P[UAS-Arm*] (D–F) or P[UAS-DisArmed] (G–I) transgenes. Activation of Wnt signaling by Arm* or DisArmed expression inhibits reporter expression in most of the circulating hemocytes. (<b>J</b>) Quantification of the data (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004509#s4" target="_blank">Materials and Methods</a>) using 5 larvae for each genotype and 10–15 hemocytes per larvae. ***p<0.001.</p> 2014-08-21 03:37:13 High Mobility Group repression tcf controls prohemocytic differentiation DNA binding domains protease digestion studies domain binding HMG sites target gene expression Bipartite DNA Recognition Helper sites mechanism Drosophila Hematopoietic System Wnt transcriptional responses