The minR reporter is repressed by Wnt signaling in circulating larval hemocytes.
Chen U. Zhang
Timothy A. Blauwkamp
Peter E. Burby
Ken M. Cadigan
10.1371/journal.pgen.1004509.g010
https://plos.figshare.com/articles/figure/_The_minR_reporter_is_repressed_by_Wnt_signaling_in_circulating_larval_hemocytes_/1147827
<p>(<b>A–I</b>) Micrographs of mid 3<sup>rd</sup> instar larval (∼88–96 AEL) circulating hemocyte smears from strains containing the minR reporter, P[He-Gal4] and P[UAS-GFP] and either + (A–C), P[UAS-Arm*] (D–F) or P[UAS-DisArmed] (G–I) transgenes. Activation of Wnt signaling by Arm* or DisArmed expression inhibits reporter expression in most of the circulating hemocytes. (<b>J</b>) Quantification of the data (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004509#s4" target="_blank">Materials and Methods</a>) using 5 larvae for each genotype and 10–15 hemocytes per larvae. ***p<0.001.</p>
2014-08-21 03:37:13
High Mobility Group
repression
tcf
controls prohemocytic differentiation
DNA binding domains
protease digestion studies
domain binding HMG sites
target gene expression
Bipartite DNA Recognition
Helper sites
mechanism
Drosophila Hematopoietic System
Wnt transcriptional responses