%0 Figure %A Briganti, Stefania %A Flori, Enrica %A Bellei, Barbara %A Picardo, Mauro %D 2014 %T Summary scheme of possible role of PPARĪ³ modulation in counteracting PUVA-SIPS of HDFs. %U https://plos.figshare.com/articles/figure/_Summary_scheme_of_possible_role_of_PPAR_947_modulation_in_counteracting_PUVA_SIPS_of_HDFs_/1131315 %R 10.1371/journal.pone.0104045.g010 %2 https://ndownloader.figshare.com/files/1626094 %K Biochemistry %K enzymology %K Enzyme chemistry %K Enzyme regulation %K enzymes %K hydrolases %K Collagenases %K lipids %K Lipid structure %K sterols %K cytochemistry %K cell biology %K Cellular structures and organelles %K Cell membranes %K Membrane characteristics %K membrane composition %K dermatology %K Photodermatology and skin aging %K modulation %K counteracting %K puva-sips %X

PUVA exposure induced intracellular generation of ROS, alteration of mitochondria function, activation of antioxidant stress response and MAPK phosphorylation pathway, dysregulation of membrane lipid metabolism, DNA-oxidative damage and altered expression of cell cycle regulators. PPARĪ³ modulation by Octa may counteract PUVA-induced senescence-like phenotype. Moreover, Octa ability to reduce phospholipid oxidation and oxysterol generation contributes to the reduction of PUVA-induced inflammatory response and redox imbalance.

%I PLOS ONE