TY - DATA T1 - Proposed molecular mechanisms of H2O2-evoked vasoconstriction, based on the present study. PY - 2014/08/05 AU - Viktória Csató AU - Attila Pető AU - Ákos Koller AU - István Édes AU - Attila Tóth AU - Zoltán Papp UR - https://plos.figshare.com/articles/figure/_Proposed_molecular_mechanisms_of_H_2_O_2_evoked_vasoconstriction_based_on_the_present_study_/1130115 DO - 10.1371/journal.pone.0103858.g007 L4 - https://ndownloader.figshare.com/files/1624517 KW - physiology KW - Cardiovascular physiology KW - Blood circulation KW - microcirculation KW - Vascular medicine KW - Vascular diseases KW - Peripheral vascular disease KW - vasoconstriction KW - molecular KW - mechanisms N2 - H2O2 may induce both vasodilation and vasoconstriction, depending on the applied H2O2 concentration, vessel type, species and experimental protocol (e.g. exposure time). Our data imply that H2O2 elicits vasoconstriction by activating Src kinase, which activates the phospholipase C (PLC), protein kinase (PKC), phospholipase A (PLA) and cyclooxygenase (COX) pathway, leading to the production of thromboxane A2 (TXA2), which increases the Ca2+ sensitivity of the vascular smooth muscle in skeletal muscle arterioles of the rat (DAG: diacylglycerol). ER -