TY - DATA T1 - H2O2 increases the Ca2+ sensitivity of force production in vascular smooth muscle cells. PY - 2014/08/05 AU - Viktória Csató AU - Attila Pető AU - Ákos Koller AU - István Édes AU - Attila Tóth AU - Zoltán Papp UR - https://plos.figshare.com/articles/figure/_H_2_O_2_increases_the_Ca_2_sensitivity_of_force_production_in_vascular_smooth_muscle_cells_/1130113 DO - 10.1371/journal.pone.0103858.g006 L4 - https://ndownloader.figshare.com/files/1624514 KW - physiology KW - Cardiovascular physiology KW - Blood circulation KW - microcirculation KW - Vascular medicine KW - Vascular diseases KW - Peripheral vascular disease KW - vasoconstriction KW - vascular N2 - The changes in intracellular Ca2+ levels and arteriolar diameters were studied in skeletal muscle arterioles under control conditions (panel A; n = 5 arterioles from 3 different animals), or after treatment with norepinephrine (panel B; n = 5 arterioles from 3 different animals), or by addition of the TXA2 receptor agonist U46619 (0.1 nM–10 µM; panel C; n = 5 arterioles from 4 different animals). Experiments were also performed in the presence of H2O2 together with Src kinase inhibitor, (Src inhibitor-1, 5 µM n = 4 arterioles from 3 different animals, 20-min preincubation; panel D). Asterisks denote significant differences from the initial values. ER -