%0 Figure %A Csató, Viktória %A Pető, Attila %A Koller, Ákos %A Édes, István %A Tóth, Attila %A Papp, Zoltán %D 2014 %T H2O2 increases the Ca2+ sensitivity of force production in vascular smooth muscle cells. %U https://plos.figshare.com/articles/figure/_H_2_O_2_increases_the_Ca_2_sensitivity_of_force_production_in_vascular_smooth_muscle_cells_/1130113 %R 10.1371/journal.pone.0103858.g006 %2 https://ndownloader.figshare.com/files/1624514 %K physiology %K Cardiovascular physiology %K Blood circulation %K microcirculation %K Vascular medicine %K Vascular diseases %K Peripheral vascular disease %K vasoconstriction %K vascular %X

The changes in intracellular Ca2+ levels and arteriolar diameters were studied in skeletal muscle arterioles under control conditions (panel A; n = 5 arterioles from 3 different animals), or after treatment with norepinephrine (panel B; n = 5 arterioles from 3 different animals), or by addition of the TXA2 receptor agonist U46619 (0.1 nM–10 µM; panel C; n = 5 arterioles from 4 different animals). Experiments were also performed in the presence of H2O2 together with Src kinase inhibitor, (Src inhibitor-1, 5 µM n = 4 arterioles from 3 different animals, 20-min preincubation; panel D). Asterisks denote significant differences from the initial values.

%I PLOS ONE