%0 Figure %A Csató, Viktória %A Pető, Attila %A Koller, Ákos %A Édes, István %A Tóth, Attila %A Papp, Zoltán %D 2014 %T H2O2-induced vasoconstriction is mediated by COX-1. %U https://plos.figshare.com/articles/figure/_H_2_O_2_induced_vasoconstriction_is_mediated_by_COX_1_/1130110 %R 10.1371/journal.pone.0103858.g004 %2 https://ndownloader.figshare.com/files/1624511 %K physiology %K Cardiovascular physiology %K Blood circulation %K microcirculation %K Vascular medicine %K Vascular diseases %K Peripheral vascular disease %K vasoconstriction %K mediated %X

Arteriolar constrictions (control, as given in Fig. 1A, closed symbols) were prevented in the presence of the non-specific COX inhibitor indomethacin (10 µM, n = 5 arterioles from 4 different animals, preincubation for 30 min, id: 111±3 µm, open symbols; panel A). Panel B: The roles of COX isoforms in H2O2-evoked responses were studied by comparing vascular diameters in the absence of COX inhibitors (dotted line) with those in the presence of COX-1 inhibitor SC-560 (1 µM, n = 5 arterioles from 3 different animals, id: 113±14 µm; open squares) or with COX-2 inhibitor celecoxib (3 µM, n = 4 arterioles from 4 different animals, id: 146±13 µm; open triangles). Asterisks denote significant differences from the control.

%I PLOS ONE