Sin, Jon M. Puccini, Jenna Huang, Chengqun H. Konstandin, Mathias E. Gilbert, Paul A. Sussman, Mark A. Gottlieb, Roberta Feuer, Ralph Exercise-induced cardiac hypertrophy in adult mice infected with CVB3 at an early age leads to dilated cardiomyopathy. <p>Three day-old mice were infected with eGFP-CVB3 (10<sup>5</sup> pfu IP) or mock-infected. After 13 weeks, swimming exercise was used to induce physiologic hypertrophy in surviving mice. <i>(A)</i> Virus-infected mice (nā€Š=ā€Š5) showed a significant increase (*p<0.05; Student's T-test) in heart weight to tibia length ratio following a 21 day swimming procedure compared to mock-infected control mice (nā€Š=ā€Š4). <i>(B)</i> Hearts of infected mice displayed cardiac hypertrophy by H&E staining. <i>(C)</i> Higher magnification of heart sections stained by H&E and Masson trichrome revealed signs of inflammation and fibrosis (respectively) in infected mice following the swimming procedure. <i>(D)</i> Little to no T cell infiltration was observed in the heart following the swimming procedure in both infected and mock-infected mice. Representative slide scanner images or microscopic images for three infected or mock-infected mice are shown.</p> cell biology;Cellular types;Animal cells;stem cells;developmental biology;microbiology;Medical microbiology;Microbial pathogens;Animal models of infection;Virology;cardiology;Cardiovascular diseases;cardiomyopathies;Pediatric cardiology;Pathology and laboratory medicine;pathogenesis;Host-pathogen interactions;cardiac;hypertrophy;mice;infected;cvb3;leads;dilated 2014-07-31
    https://plos.figshare.com/articles/figure/_Exercise_induced_cardiac_hypertrophy_in_adult_mice_infected_with_CVB3_at_an_early_age_leads_to_dilated_cardiomyopathy_/1123899
10.1371/journal.ppat.1004249.g010