%0 Journal Article %A L. Novoa, María %A Escalante, Yelisbeth %A Maldonado, Liliana %A Galindo-Castro, Iván %A Álvarez, Annamil %A Figarella, Katherine %A Marsiccobetre, Sabrina %A Arocha, Irina %A Nieves, Jais %A Salazar, Franklin %A Gámez, Carlos %A Canudas, Nieves %A Tropper, Eleonora %A González, Teresa %A E. Villamizar, José %D 2014 %T Synthesis and biological evaluation of ( − )-13,14-dihydroxy-8,11,13-podocarpatrien-7-one and derivatives from (+)-manool %U https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_biological_evaluation_of_160_8722_160_13_14_dihydroxy_8_11_13_podocarpatrien_7_one_and_derivatives_from_manool/1121641 %R 10.6084/m9.figshare.1121641.v24 %2 https://ndownloader.figshare.com/files/1614112 %K compound 1 %K cytotoxic activity %K ring C %K compound 7 %K trypanocidal activities %K diterpene derivatives %K manool %X

13,14-Dihydroxy-8,11,13-podocarpatrien-7-one (1) and a series of ring C aromatic diterpene derivatives were synthesised from (+)-manool (4) and evaluated for their cytotoxic, leishmanicidal and trypanocidal activities. Our results indicated that compound 1 and other podocarpane-type intermediates are cytotoxic. Cleavage of C6–C7 bond of compound 7 improved cytotoxic activity, indicating that, in particular, the 6,7-seco-podocarpane-type compound 20 might serve as a lead compound for further development.

%I Taylor & Francis