Synthesis and biological evaluation of ( − )-13,14-dihydroxy-8,11,13-podocarpatrien-7-one and derivatives from (+)-manool María L. Novoa Yelisbeth Escalante Liliana Maldonado Iván Galindo-Castro Annamil Álvarez Katherine Figarella Sabrina Marsiccobetre Irina Arocha Jais Nieves Franklin Salazar Carlos Gámez Nieves Canudas Eleonora Tropper Teresa González José E. Villamizar 10.6084/m9.figshare.1121641.v24 https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_biological_evaluation_of_160_8722_160_13_14_dihydroxy_8_11_13_podocarpatrien_7_one_and_derivatives_from_manool/1121641 <div><p>13,14-Dihydroxy-8,11,13-podocarpatrien-7-one (<b>1</b>) and a series of ring C aromatic diterpene derivatives were synthesised from (+)-manool (<b>4</b>) and evaluated for their cytotoxic, leishmanicidal and trypanocidal activities. Our results indicated that compound <b>1</b> and other podocarpane-type intermediates are cytotoxic. Cleavage of C6–C7 bond of compound <b>7</b> improved cytotoxic activity, indicating that, in particular, the 6,7-<i>seco</i>-podocarpane-type compound <b>20</b> might serve as a lead compound for further development.</p></div> 2014-12-20 17:43:47 compound 1 cytotoxic activity ring C compound 7 trypanocidal activities diterpene derivatives manool