Statin treatment and <i>P. aeruginosa</i> infection modulate the host immune response.
Emma Hennessy
Julie O'Callaghan
Marlies J. Mooij
Claire Legendre
Olga Camacho-Vanegas
Sandra C. Camacho
Claire Adams
John A. Martignetti
Fergal O'Gara
10.1371/journal.pone.0102200.g001
https://plos.figshare.com/articles/figure/_Statin_treatment_and_P_aeruginosa_infection_modulate_the_host_immune_response_/1099267
<p>A549 cells were treated with 10 µM simvastatin or an equivalent amount of DMSO (VEHICLE) for 24 hours. Untreated and statin-treated cells were subsequently infected with <i>P. aeruginosa</i> PAO1 for 3 hours at MOI 50∶1. The expression of (<b>A</b>) KLF2 (<b>B</b>) KLF6 (<b>C</b>) IL-8 (<b>D</b>) CCL20 and (<b>E</b>) TLR5 was analysed in uninfected cells, and in the presence of vehicle, simvastatin (SIM), <i>P. aeruginosa</i> (PAO1) and simvastatin and PAO1 combined (SIM+PAO1). *<i>P</i>, ≤0.05, **<i>P</i>, ≤0.01, ***<i>P</i>, ≤0.001.</p>
2014-07-10 02:59:17
cell biology
Molecular cell biology
genetics
gene expression
immunology
Immune response
inflammation
Immune system
Innate immune system
immunity
Immune activation
microbiology
bacteriology
Gram negative bacteria
Medical microbiology
Microbial pathogens
Bacterial pathogens
Infectious diseases
Bacterial diseases
Pseudomonas infections
Pathology and laboratory medicine
pathogenesis
Host-pathogen interactions
modulate