Caspase 9 activation <i>en route</i> to apoptosis.
Ingo Staudacher
Julian Jehle
Kathrin Staudacher
Hans-Werner Pledl
Dieter Lemke
Patrick A. Schweizer
Rüdiger Becker
Hugo A. Katus
Dierk Thomas
10.1371/journal.pone.0088164.g006
https://plos.figshare.com/articles/figure/_Caspase_9_activation_en_route_to_apoptosis_/1076191
<p>(A, B) Increased levels of cleaved caspase 9 and unaffected total caspase 9 protein expression were detected in LNT-229 cells treated with doxazosin. Representative Western blots and mean (± SEM) optical densities normalized to doxazosin-free conditions are presented for cells exposed to increasing concentrations of doxazosin (n = 3 independent assays; **p<0.01; GAPDH, glyceraldehyde-3-phosphate dehydrogenase).</p>
2014-02-06 10:45:34
Anatomy and physiology
Neurological system
Nerve tissue
electrophysiology
genetics
Cancer genetics
Molecular cell biology
Signal transduction
Signaling in cellular processes
Antiapoptotic signaling
Apoptotic signaling
Signaling in selected disciplines
Oncogenic signaling
Cell death
Membranes and sorting
cardiovascular
arrhythmias
Cardiovascular pharmacology
Heart failure
Drugs and devices
Drug research and development
drug discovery
oncology
Basic cancer research
Tumor physiology
activation