Caspase 9 activation <i>en route</i> to apoptosis. Ingo Staudacher Julian Jehle Kathrin Staudacher Hans-Werner Pledl Dieter Lemke Patrick A. Schweizer Rüdiger Becker Hugo A. Katus Dierk Thomas 10.1371/journal.pone.0088164.g006 https://plos.figshare.com/articles/figure/_Caspase_9_activation_en_route_to_apoptosis_/1076191 <p>(A, B) Increased levels of cleaved caspase 9 and unaffected total caspase 9 protein expression were detected in LNT-229 cells treated with doxazosin. Representative Western blots and mean (± SEM) optical densities normalized to doxazosin-free conditions are presented for cells exposed to increasing concentrations of doxazosin (n = 3 independent assays; **p<0.01; GAPDH, glyceraldehyde-3-phosphate dehydrogenase).</p> 2014-02-06 10:45:34 Anatomy and physiology Neurological system Nerve tissue electrophysiology genetics Cancer genetics Molecular cell biology Signal transduction Signaling in cellular processes Antiapoptotic signaling Apoptotic signaling Signaling in selected disciplines Oncogenic signaling Cell death Membranes and sorting cardiovascular arrhythmias Cardiovascular pharmacology Heart failure Drugs and devices Drug research and development drug discovery oncology Basic cancer research Tumor physiology activation